Functional sites and evolutionary connections of acylhomoserine lactone synthases
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چکیده
منابع مشابه
Functional sites and evolutionary connections of acylhomoserine lactone synthases.
Acylhomoserine lactone (AHL) synthases act as chemical communication signals or pheromones in Gram-negative bacteria and regulate diverse physiological events in a cell density-dependent manner. The recent crystal structure determination of EsaI, a key enzyme in this pathway, shows that the AHL synthase superfamily members adopt the fold of the N-acetyltransferase superfamily. We suggest, by th...
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Acylhomoserine lactones, which serve as quorum-sensing signals in gram-negative bacteria, are produced by members of the LuxI family of synthases. LuxI is a Vibrio fischeri enzyme that catalyzes the synthesis of N-(3-oxohexanoyl)-L-homoserine lactone from an acyl-acyl carrier protein and S-adenosylmethionine. Another V. fischeri gene, ainS, directs the synthesis of N-octanoylhomoserine lactone....
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 2003
ISSN: 1741-0134,1741-0126
DOI: 10.1093/proeng/gzg031